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Firstly, adipose tissue produces interleukin-6 (IL-6) that stimulates the absorption of dopamine creating a feeling of satiety, which has a direct effect on weight control

The induction of VPS8, POLRMT, and IGFBP5 GPs at the end of 4th week during 4-week intermittent fasting preceded the significant reduction in insulin resistance estimated by HOMA-IR that occurred 1 week after 4-week intermittent fasting

Butyrate, serving as the primary energy source for intestinal epithelial cells, not only maintains colonic barrier function but also alleviates inflammatory responses by inhibiting the NF-B signaling pathway (161, 162)