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Arch Intern Med 171(6):507515 Li C, Ford ES, Zhao G, Balluz LS, Giles WH, Liu S (2011b) Serum -carotene concentrations and risk of death among US adults: The third national health and nutrition examination survey follow-up study

Surprisingly, while approximately 53% of -hydroxybutyrylated proteins contain only one Kbhb site, others harbor multiple or even more than ten Kbhb sites, as demonstrated in HEK293T cells treated with 10 mM BHB (Huang et al., 2021)

Interestingly, preclinical models have shown that curcumin can decrease the expression of Th1 cytokines (IL-12, IFN-gamma, TNF-alpha, IL-1) and increase the expression of Th2 cytokines (IL-4 and IL-10) in colon mucosa, promoting a shift from Th1 to Th2 [510]

[3] The lipoyl domain itself is attached by a flexible linker to the E2 core and the number of lipoyl domains varies from one to three for a given organism