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A vial labeled "5 mg" from one compounder may differ meaningfully from another, raising the practical risk of accidental misdosing even when a patient follows a physician's written protocol

Because it is unlikely that Glu would be modified by 4-OXO-DHA, our results support that 4-OXO-DHA (an electrophilic Michael acceptor) can covalently bind to the peptide containing the sequence of the active site of NF-B p50 protein to form a covalent linkage with the nucleophilic Cysteine-S 62 residue (marked in bold and italic in Table 1)

A general feeling of discomfort, uneasiness, or being unwell