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The study was designed as proof of concept for NNMT as a drug-development target

You can ask your doctor to do a blood test if you're worried you may have a vitamin B12 deficiency.

Additionally, analogues containing the quinolinium scaffold lacked inhibitory activity against enzymes in the NAD + salvage pathway that bind nicotinamide-containing substrate, including NAMPT[27, 32] and the NAD + -dependent SIRT1 enzyme, which deacetylates NAD + to produce NA, a product inhibitor of SIRT1.[33] These results suggest that quinolinium-based NNMT inhibitors achieve selectivity by specifically interacting with the NA-binding pocket of NNMT,[17] unlike several known non-selective methyltransferase inhibitors that interact with the SAM-binding pocket, which is highly conserved among SAM-dependent methyltransferases.[34, 35] Membrane-permeable NNMT inhibitors reduced intracellular 1-MNA levels in a concentration-dependent manner and at pharmacologically relevant concentrations that did not impact cell viability, suggesting these small molecules interact directly with NNMT in cells

Components: CJC-1295 (no DAC) + Ipamorelin: 300mcg each subcutaneous before bed AOD-9604: 500mcg subcutaneous morning (fasted) 5-Amino-1MQ: 50mg oral once daily Schedule: Daily for AOD-9604 and 5-Amino-1MQ