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Mol Med Rep 21(6):24662474 Wang Q, Liang YY, Li KW, Li Y, Niu FJ, Zhou SJ, Wei HC, Zhou CZ (2021a) Herba Siegesbeckiae: a review on its traditional uses, chemical constituents, pharmacological activities and clinical studies

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It is always best for a dermatologist to evaluate the cause of a persons dark patches

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Modifications in the test polypeptide can be introduced by, e.g., error-prone PCR, shuffling, oligonucleotide-directed mutagenesis, assembly PCR, sexual PCR mutagenesis, in vivo mutagenesis, cassette mutagenesis, recursive ensemble mutagenesis, exponential ensemble mutagenesis, site-specific mutagenesis, gene reassembly, gene site saturated mutagenesis (GSSM), synthetic ligation reassembly (SLR) and/or a combination thereof

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