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Glutamic acid is an excitotoxic amino acid that enhances GBM invasion (1, 80, 81, 86, 9396)

Effects of vitamin A supplementation on immune responses and correlation with clinical outcomes

Although the mechanisms are yet to be fully understood, most of the proposed mechanisms involve extrinsic and intrinsic apoptotic pathways, where DR5, PUMA and Bim are upregulated and the expression of antiapoptotic proteins, such as survivin and Bcl-2 is diminished [119,120]

These metabolites influence the survival and function of neighboring cells within the same environment, thereby establishing bidirectional metabolic communication between T cells and their surroundings