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The role of SENP2 was confirmed in vivo using adipocyte-specific Senp2 knockout ( Senp2 -aKO) mice

Extrinsic apoptosis is initiated through the activation of caspase-8, while intrinsic apoptosis is mediated by the mitochondrial release of cytochrome c and SMAC/DIABLO, leading to the activation of caspase-9, which in turn activates downstream effector caspases such as caspase-3 and caspase-7 [112, 114]

Similar content being viewed by others Main Acute myeloid leukemia (AML) is a complex and heterogeneous hematologic malignancy characterized by rapid proliferation of myeloblasts in the bone marrow