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Int Immunopharmacol 10(12):15801586

High fat diet (HFD)-induced obesity altered the circulating IGF cascade and increased circulatory level of total IGF-1, IGF-2, free IGF-1, and IGFBP3 in rodent and clinical trials [157, 158]

Given the potential adverse effects of hyperuricemia on kidney function, we measured serum biochemical markers such as blood urea nitrogen (BUN) and creatinine (CREA)

Tolerability and Safety Questions Both candidates are likely to be judged partly on gastrointestinal tolerability: nausea, vomiting, diarrhea, constipation, dose escalation, and discontinuation due to adverse events