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ScRNA-seq has uncovered pronounced endothelial heterogeneity in kidney injury, identifying aberrantly activated endothelial subsets, such as Rap guanine nucleotide exchange factor 5 (Rapgef5) + and membrane-associated guanylate kinase, WW and PDZ domain containing 1 (Magi1) + cells, that are associated with defective angiogenesis and sustained endothelial activation [63]

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