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for example, mitochondrial autophagy (mitophagy) mediated by PINK1/Parkin, mitochondrial dynamics (fusion/fission), or mitochondrial DNA (mtDNA) damageall of which are linked to oxidative stresshave not been rigorously evaluated for their direct contribution to ferroptosis initiation or suppression

In general, without wishing to be bound to any theory, receptor-mediated transcytosis occurs in three steps: receptor-mediated endocytosis of the agent at the luminal (blood) side, movement through the endothelial cytoplasm, and exocytosis of the drug at the abluminal (brain) side of the brain capillary endothelium

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