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C.MunusamyM.WibowoM.LiangZ

Under hyperglycemic conditions, Mller cells experience oxidative stress, inflammation, and mitochondrial dysfunction, leading to neuronal damage and neuroinflammation (202205)

We propose that an age-related oxidative redox shift overwhelms energetic capacity to promote pathogenic impairment of proteostasis and downstream synapse loss and cognitive decline in AD

To monitor ROS dynamics in mitochondria, we first co-expressed the superoxide-generating protein tandem-KillerRed (KR) and H 2 O 2 biosensor HyPer7, both targeted into the matrix of mitochondria in HEK293T cells and later in mouse embryonic fibroblasts (MEFs)