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Rating: 4.1377 (15 reviews)

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The study found that females with obesity had a 52% faster AER than those with normal weight (116) (For an example of AER for individuals with different BMI, see Figure 8)

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Besides DNA breaks, PARP1 also recognizes nicks or flaps in the normal replication intermediates like unligated Okazaki fragments and becomes activated during the S phase (Azarm and Smith, 2020