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Future clinical research endeavors should consider the various features that modulate NIMETOX pathways, specifically the ROI and MetS, as well as the various phenotypes of MDD and the phase of the index episode, when this disorder is investigated through the application of advanced machine learning-based composite scores to assess NIMETOX functions

Open-source packages and libraries and corresponding versions used during the computational analysis are described in the Methods and Reporting Summary

Importantly, that study was conducted in cells that had been pretreated with the p53 stabilizer nutlin-3

Role of IGF-Binding Proteins in Regulating IGF Responses to Changes in Metabolism