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doi: 10.3389/fphar.2025.1719384 Received 06 October 2025 Revised 01 November 2025 Accepted 03 November 2025 Published 26 November 2025 Volume 16 - 2025 Edited by Gvozden Rosic, University of Kragujevac, Serbia Reviewed by Kandasamy Neelamegam, Tulane University, United States Ciniraj Raveendran, Government Medical College, India Updates Copyright 2025 Yan, Song, Zhang, Hu, Wang, Guo, Wang, Ma and Liu

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Soon, fluid and waste flood the area, often overwhelming it

452 Endothelial cells exhibit enhanced NO production and concurrent suppression of endothelin formation, resulting in vascular smooth muscle relaxation and vasodilation mediated by the endothelium (e.g., GLP-1, exenatide, and liraglutide)