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Among these, alpha-linolenic acid (-LA, an -3) and linoleic acid (LA, an -6) are defined as essential fatty acids since they cannot be synthesized in human body, and their intake fully depends on the diet [119]

et al., 2008)

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Genome-wide association studies on COPD have demonstrated that FAM13A (family with sequence similarity 13 member A) enhances FAO by upregulating CPT1A expression, while chemical or genetic inhibition of FAO attenuates the accumulation of mitochondrial-derived reactive oxygen species (ROS) and cell death induced by CS exposure in vitro and in vivo (Jiang et al., 2017)