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Such a role would be consistent with the fact that the UPR also upregulates ERO1 expression, suggesting that augmenting ER oxidative folding is part of the UPR adaptive program

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14 NAD + biosynthesis De novo pathway Mammalian cells can generate NAD + de novo from dietary tryptophan (Trp) by the kynurenine pathway (KP), which is initialized by either TDO or IDO