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Effects of Long-Term exposure to copper on the Keap1/Nrf2 signaling pathway and Msr-Related redox status in the kidneys of rats

[99] One in vitro study suggests a selenium-containing antioxidant compound called Ebselen (2-phenyl-1,3-benzisoselenazol-3(2H)one) has a mild inhibitory effect on the anti-tumor effect of bleomycin

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Furthermore, environmental pollutants, determining the formation of DNA adducts and abasic sites construction, can induce DNA modifications in gametes and embryos by introducing genetic mutations once unrepaired ( Nutritional Disorders A normal reproductive performance definitely requires a healthy nutrition since malnourished males and females are reported as major infertile populations in developing countries while, eating in excess, fast food consumption, hypercaloric dietary regimens and obesity, concur to infertility in well-developed and western societies