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Description

Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens

10.1007/s12672-023-00670-x Discov

Another study found a strong association between plasma TNF- levels and KYN as well as KYN/TRP ratios, and patients with higher levels showed greater MDD severity and poor treatment response [104]