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For instance, combined exposure to fine particulate matter (PM 2.5 ), ozone (O 3 ), and nitrogen dioxide (NO 2 ) during endurance exercise has been shown to significantly enhance both airway and systemic inflammation, elevate circulating neutrophil levels, and impair mucosal immune protection (197, 198)

Taken together, these findings position naringenin as a multifaceted compound with the potential to target several pathological features of AD simultaneously

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High-fat, Western-style diets, characterized by high saturated fats, refined sugars, and low fiber, have been associated with gut dysbiosis, increased neuroinflammation, and exacerbation of Alzheimers pathology, including A aggregation and tau hyperphosphorylation