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Zhai Y, Zhu C, Zhu T, Song W, Tang Y, Jiang L, Wu Q (2025) Global, regional, and national burden of chronic respiratory diseases, 19902021 and predictions to 2035: analysis of data from the global burden of disease study 2021

10.1186/s12970-019-0303-x 121 OnoK.YoshiikeY.TakashimaA.HasegawaK.NaikiH.YamadaM

This high dose was chosen because it was below a previously determined maximum-tolerated dose, and it was based on a prior erroneous study that indicated NAC had low bioavailability

GSTT1-null individuals have reduced capacity to conjugate and excrete these compounds increasing their intracellular residence time and reactivity with DNA and protein