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Description

xCT inhibition increases sensitivity to vorinostat in a ROS-dependent manner

The mechanism is relevant to hemorrhoidal inflammation, but clinical translation hasn't occurred

It was observed in case of influenza virus that it can transmit more readily at lower temperatures (Lowen and Steel, 2014), since host immunity is likely to remain weakened in cold weather, this can further increase the vulnerability toward infection (Kudo et al., 2019)