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& Sorbi, S

These include dedifferentiation, activation of the cell cycle, modulation of endogenous hormone biosynthesis, and extensive physiological, metabolic, and gene-expression reorganization, along with epigenetic regulation [44,45,46,47]

Third, research remains unbalanced, focusing mainly on macrophages while underexploring ferroptosis interplay with neutrophils, dendritic cells, and lymphocytes, thus hindering a full view of the periodontal immunopathological network (64, 112, 113)