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These observations suggest that the consumption of cysteine and GSH in the presence of 3MP in cells expressing 3MST is due to the production of Cys-SSH, GSSH, GSSG and their polysulfide counterparts (Cys-SS n H, GSS n H, and GSS n G, n 2)

The induction of stress by therapy could affect tumor cells in different ways: including the induction of autophagy, cellular senescence, apoptosis, or necrosis, all of which are, in part, interconnected, and damages induced by therapyeither chemo- or radiotherapy could induce autophagy as a housekeeping process (Kanzawa et al., 2012)

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