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One possible improvement (intrinsically offered by the time-domain approach since the arrival time of detected photons encodes the average investigated depth 9 ) could be the use of DTOF derived optical properties and/or magnetic resonance imaging derived information on the head geometry, which could both lead to defining optimal gate parameters on an individual basis

Table three, which you can check out in the article, is really good because it goes over all the differential diagnoses and the etiology, the clinical presentation, the image findings, the physical examples, all in one table, which is really cool