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The localized effects sustain collagen support even without systemic administration

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there is the potential for: Ischemic injury due to potent vasoconstrictor action and tissue hypoxia Mild bradycardia, probably as a reflex result of a rise in blood pressure Arrhythmias Anxiety Transient headache Respiratory difficulty Pharmacokinetics: When released from nerve terminals, its actions are primarily (75%) terminated by neuronal reuptake Diffusion and degredation by extracellualr COMT contribute to a lesser extent