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Moreover, recent evidence points to another driver of the disease: vitamin D deficiency [113, 114]

Calabrese G, Peker E, Amponsah PS et al (2019) Hyperoxidation of mitochondrial Peroxiredoxin limits H(2) O(2)-induced cell death in yeast

Chronic and high-dose alcohol exposure inhibits autophagy, 88,89 and inhibiting autophagy results in hepatocyte death

This includes the dynamic interplay between host immune responses and bacterial evasion, the genetic mutations that confer classical drug resistance, the epigenetic regulation in bacterial persistence and adaptive changes in bacterial cell wall architecture and core metabolism