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Many automatically think that if you have an MTHFR defect, then you need the B12 form, methylcobalamin, but this is simply NOT true

Injectable BPC-157 demonstrates superior bioavailability and clinical efficacy compared to oral formulations, with studies showing injectable forms achieve 85-95% absorption versus 15-30% for oral capsules

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Strongest human evidence The METAOD006 (OPTIONS) Phase 2b trial randomized 502 adults with obesity (BMI 30-45 kg/m^2) to oral AOD-9604 (0.25, 0.5, or 1 mg/day) or placebo for 24 weeks alongside a supervised diet and exercise program