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Whether administration of leptin could overcome leptin resistance and exert an anti-obesity effect was tested in a placebo-controlled study with 47 obese men and women given varying doses of recombinant human leptin (0.03 mg/kg and 0.30 mg/kg, respectively) for 24 weeks and advised to eat 500 kcal less than body requirements each day

Epidemiology (Study of disease distribution and patterns in populations) Thalassemia is one of the most widely distributed genetic blood disorders globally, affecting millions of individuals either as carriers or as patients with clinically significant disease