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This is in consistent with another study showing that pre-treatment with triptolide, a diterpenoid epoxide protected Wistar rat from myocardial ischemia/reperfusion injuries by suppressing the production of pro-inflammatory cytokines (TNF-, IL-1, and IL-6) and inducing Nrf2-regulated antioxidant enzymes (SOD, GSH, GPx, and HO-1) (Yu et al., 2016)

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However, after hepatic metabolism by CYP450 enzymes, they are converted into reactive pyrrole metabolites (e.g., dehydropyrrole), which can form covalent adducts with DNA, RNA, and proteins