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Acid-degradable core-shell nanoparticles for reversed tamoxifen-resistance in breast cancer by silencing manganese superoxide dismutase (MnSOD)

Cytosolic and mitochondrial glutathione peroxidases (cGPXs or GPX1) reduce only soluble hydroperoxides, such as H 2 O 2 , and some organic hydroperoxides, such as hydroperoxy fatty acids, cumene hydroperoxide or t-butyl hydroperoxide