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Figure 2 3.1 Activation of inflammatory signaling pathways Research indicates that increased intestinal permeability allows endotoxins such as LPS to enter the systemic circulation, where they trigger systemic inflammatory responses by activating the Toll-like receptor 4/nuclear factor kappa-light-chain-enhancer of activated B cells (TLR4/NF-B) inflammatory pathway

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Given that AGERAGE signaling is known to activate inflammatory and oxidative pathways 76 , our findings support the interpretation that chronic dietary AGE exposure is associated with testicular redox imbalance

However, a key problem of drug repurposing is the lack of single-agent activity, its feasibility should be examined in further studies (112)