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WT mice were unilaterally injected with AAV- hSyn - SNCA or - GPX4 into the substantia nigra as described above to obtain strains overexpress human -synuclein, GPX4, or both

COVID-19 viral RNA and antigens have been detected in the cerebrospinal fluid and the brain tissue, indicating that the virus can cross the bloodbrain barrier to invade the central nervous system ( via extracellular vesicles and direct intercellular transmission ( The COVID-19 virus can colonize the brain, leading to neuronal death and inflammation ( COVID-19 can induce cytokine storms and neuroinflammation, leading to neuronal damage and decreased cognitive function

After paraffin sections were dewaxed and hydrated, endogenous peroxidase activity was blocked using 3% hydrogen peroxide

In other embodiments, the oligonucleotide has one to seven, one to five, or one to three phosphodiester linkages