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For instance, in human coronary artery endothelial cells, selective inhibition of PKC- by RBX during simulated ischemiareperfusion significantly restored Akt activation, enhanced anti-apoptotic signaling (iNOS, p-BAD), and suppressed pro-apoptotic mediators (p-FOXO, cleaved PARP, and caspase-3), thereby attenuating endothelial injury and supporting cardiovascular protection in both diabetic and non-diabetic settings [171]

In the present study, both SOD1 and GPx expressions were significantly upregulated in the animals subjected to CSD and treated with ALA (Figure 3)

The hippocampus, critical for memory and learning, exhibits lower methylation in active enhancers during early developmental stages (post-conceptional week 17