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CNS Neurol Disord Drug Targets 16:425439

Safety and Limitations of Existing Studies Although preclinical and early human studies suggest that Ipamorelin stimulates growth hormone selectively and without major adverse effects, its clinical use has not been approved by regulatory authorities for routine medical treatment

Glutaminolysis inhibitors Inhibitors of glutamine metabolism, particularly the glutaminase inhibitor CB-839 (telaglenastat), have shown efficacy in preclinical models of NSCLC as illustrated in Table 2