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Recent rat studies using oleic acid to induce AKI further report that hispidulin reverses oleic acid-associated oxidative stress, inflammatory gene expression (e.g., IL-6, NF-B), and tubular injury markers (e.g., KIM-1), again underscoring oleic acid as a lipotoxic insult model in vivo (Avci et al

Injections are generally far more effective as they work internally, while creams and serums work on the surface.

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