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Because tiotropium is a predominantly renally excreted drug, patients with moderate to severe renal impairment (creatinine clearance of 3% in the STIOLTO RESPIMAT treatment group and a higher incidence rate than the active comparator groups listed

It was found that this asymmetric structure facilitates the separation of the desired bispecific compound from unwanted immunoglobulin chain combinations, as the presence of an immunoglobulin light chain in only one half of the bispecific molecule provides for a facile way of separation

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Les formules vitent les additifs controverss et sont conues pour tre bien tolres, mme en cas de terrain sensible