foxo4-dri peptide senolytic mice 2024 mouse study 2023 Molecular modelling of the FOXO4-TP53 interaction to design peptides for the elimination of The disordered p53 transactivation domain
The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4 DRI Nature Communications foxo4 dri senolytic mouse 2023 2024 Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging: Cell FOXO4 DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53 serine 15 phosphorylation Communications Biology Computational design of peptide targeting FOXO4. a, Domains of FOXO4 Download Scientific Diagram
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