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In a human cervical cancer mouse model, combined treatment with a copper chelator and cisplatin increased the levels of cisplatin-DNA adducts in cancerous tissue without affecting normal tissue, thereby enhancing the therapeutic effect (178)

Lastly, athletes wishing to explore NO enhancers are reminded that a good level of evidence exists for L-citrulline to improve exercise performance, and therefore may consider use of this supplement whilst the intricacies of CM supplementation are discovered (Gonzalez and Trexler 2020)

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Increasing ATP availability, reducing reactive oxygen species (ROS) generation by mitochondrial complex I, inhibiting the mitochondrial permeability transition pore, and stimulating mitochondrial biogenesis, all seem to stabilize synaptic functions