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A1298C SNP (Glu 429 Ala) At nucleotide 1298 of the MTHFR, there are two possibilities: A or C

doi: 10.1016/S1474-4422(18)30499-X 14

Cognitive reserve is made from several components: (1) the brain reserve (which reflects the anatomical individual differences quantified by the number of neurons and synapses), (2) the brain maintenance supported by all homeostatic pathways from cellular to organ level), (3) the brain resilience (the ability to withstand stress without mounting the pathology) and (4) the brain compensation directly linked to the regenerative capacity of the nervous tissue