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Because it degrades in blood in a pathway involving amino-peptidases, it may not be suitable for people who take medications that inhibit or are metabolized by peptidases (e.g., captopril, a treatment for hypertension).4 Also, based on what we know about other therapeutic peptides, we would say DSIP is contraindicated for women who are pregnant or breastfeeding as well as people with a personal history of cancer

J Pharmacol Exp Ther 283 : 247258

While these peptides show strong potential in preclinical and animal studies, particularly for certain disease model they are not FDA-approved drugs and should only be used for research or educational purposes

10.1158/1940-6207.CAPR-11-0301