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There's usually a clinical reason

LeTrilling et al , 2018)

As mentioned above, RAS can also activate PI3K, triggering the PI3K/Akt/mTOR axis [111]

This means that EpCAM-specific antibodies are conjugated with cytotoxic agents, such as doxorubicin, paclitaxel, calicheamicin, topoisomerase I inhibitors, alpha amanitin, and indolinobenzodiazepine pseudodimers (IGNs), to specifically kill the EpCAM+ tumor cells