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Disclosures: Shadera Slatter: Nothing to Disclose, Jordan Guillot: Gilead Sciences: UCSF-Stanford/Gilead fellowship in Regulatory Science, Christopher Williams: Nothing to Disclose, Alexandre Watanabe: Nothing to Disclose, Eirum Chaudhri: Merck: Employee, Xiao Zhang: Merck: Employee, Gail Fernandes: Merck & Co., Inc: Hold Stocks, Merck & Co., Inc: Employee, Merck & Co., Inc: Stock - publicly traded company, Jin Ge: Merck and Co: Grant/Research Support, Iota Biosciences/Astellas Pharmaceuticals: Consultant, Madrigal Pharamaceuticals: Consultant, Gilead Sciences: Advisor, Vivek Rudrapatna: Nothing to Disclose 1133 PNPLA3 RS738409 IS SIGNIFICANTLY AND INDEPENDENTLY ASSOCIATED WITH HISTOLOGICAL PROGRESSION AND REGRESSION IN MASLD: A LARGE PAIRED AND PROSPECTIVE LIVER BIOPSY STUDY Eduardo Vilar-Gomez 1 Katherine Yates 2 David Kleiner 3 Cynthia Behling 4 Oscar Cummings 5 Laura Wilson 6 Tiebing Liang 7 Chaowapong Jarasvaraparn 8 Rohit Loomba 9 Jeffrey Schwimmer 10 Arun Sanyal 11 Jay Hoofnagle 12 Naga Chalasani 13 , 1 Indiana University School of Medicine, 2 Department of Epidemiology, Johns Hopkins University, Baltimore, MD, 3 National Cancer Institute, Bethesda, 4 University of California, San Diego, Department of Pediatrics