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A 48 hour fast can turn standard Paracetamol into acute liver failure. Fasting depletes Glutathione, leaving the liver defenseless against toxic NAPQI. Review the latest guidelines on BMJ Best Practice: https: bestpractice.bmj.com topics en us 1010 The Mechanism of Paracetamol induced Hepatotoxicity: Implications for Therapy Semantic Scholar PharmGKB summary: Pathways of acetaminophen metabolism at the therapeutic versus toxic doses PMC Reducing the effects of drug toxicity on glutathione metabolism ScienceDirect
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