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In many cases radio diagnosis like CT scan, MRI, Autopsy of brain, have shown lower iron levels in substantia nigra which is evidence for PLMS and RLS pathology [28]

When it came to analysing their results with the Poisson method, Delbrck and Luria argued 'The situation is similar to the operation of a (fair) slot machine, where the average return from a limited number of plays is probably considerably less than the input, and improbably, when the jackpot is hit, the return is much bigger than the input' (Luria, Delbrck)

A previous study suggested that excessive oxidative stress-induced impaired autophagic flux is a key pathogenic event in DED (Wang et al., 2021)