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Are you primarily focused on appetite modulation and gastric emptying as the core drivers of metabolic change

TRPV4-induced phenotypes include RGC degeneration (133), reactive gliosis (27), glial swelling (113) and increased permeability of the blood-retina barrier (127, 134) whereas mice lacking the TRPV4 gene seem to be protected from some types of mechanical and nociceptive stress (130) and do not appear to develop glaucoma (51)