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GPX2 mRNA levels were observed to be higher than in sensitive ICR/HA mice (31)

In the present study we have examined GSH changes using the most common rodent exposure regimen for chronic CS studies and have shown that there is a GSH adaptive response to CS that occurs very early on and can be maintained for periods of up to 4 months

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However, many organisms can survive without these enzymes and some organisms completely lack GR, suggesting that alternative mechanisms for regenerating GSSG may exist (Marty et al., 2009