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Such a strategy would not only inhibit the direct fibrotic actions of TGF- but also shift the macrophage phenotype from a pro-fibrotic M2 state to an anti-fibrotic M1 state, thereby addressing both the cause and the sustaining factors of fibrosis

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For years, researchers suspected it existed naturally in the human body, and in 2017, Epitalon was detected for the first time in physiological pineal gland extract, confirming it as an endogenous compound