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In more severe COPD, combination bronchodilator therapy (i.e., a rescue bronchodilator combined with a controller [long-acting] bronchodilator) may help relieve symptoms (ICSI 2011

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Buckman TD, Kling A, Sutphin MS, Steinberg A, Eiduson S

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Notably, BBB dysfunction does not occur uniformly across the brain: the hippocampus and certain cortical regions exhibit an early and more severe BBB breakdown in patients with AD [102]

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doi: 10.1158/1535-7163.MCT-07-2142

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