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However, some studies suggest that IL-1R could not directly cause cell death, so the primary mechanism of IL-1 affecting AILI may be the activation of inflammatory cells, such as neutrophils [83]

Acknowledgments NA gratefully acknowledges the partial financial supports received from FCT (Government of Portugal) through contract (SFRH/BPD/84671/2012), the Aveiro University Research Institute/CESAM (UID/AMB/50017/2013), COMPETE through Project n. FCOMP-01-0124-FEDER-02800 (FCT PTDC/AGR-PRO/4091/2012), and to FCT/MEC through national funds, and the co-funding by the FEDER, within the PT2020 Partnership Agreement and Compete 2020

Jiang W-J, Yao X-R, Zhao Y-H, Gao Q-S, Jin Q-G, Li Y-H, et al

reported that extracellular vehicles (EVs) derived from fibroblast-like synoviocytes (FLSs) in rheumatoid arthritis (RA) can promote endothelial cell (EC) angiogenesis by targeting the p53/mTOR signaling pathway through miR-1972 [39]