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Organic selenium is also safer for long-term use compared to inorganic sources like sodium selenite, reducing the risk of oversupplementation

Beyond these, the strongest genetic risk factor for sporadic AD, APOE4 , is also linked to lysosomal pathway abnormalities, including impaired lipid transport and disruption of endosomal trafficking that secondarily impacts lysosomal function [43]

Phenthoate acts via acetylcholinesterase inhibition, but its selective toxicity relies on rapid hydrolysis by carboxylesterases in mammals

Effect of thioltransferase (glutaredoxin) deletion on cellular sensitivity to oxidative stress and cell proliferation in lens epithelial cells of thioltransferase knockout mouse